Cornelia de Lange Syndrome (CdLS) is a rare congenital genetic disorder. Symptoms include delays in physical development before and after birth, abnormalities of head and facial features, malformations of hands and arms and mild to severe intellectual disability. CdLS affects males and females equally and is estimated to occur in one out of 10,000 live births. Treatment varies from case to case but typically involves a team of specialists including pediatricians, geneticists, surgeons, orthopedists, plastic surgeons, gastroenterologists and urologists. Individuals affected should receive careful and regular medical assessments. Organizations exist to provide information, support and resources to individuals and families experiencing rare disorders in their lives. Information provided in part by our partner NORD.