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What Are the 15 Types of Dysautonomia?

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What if a system in your body, responsible for functions you don’t even have to think about, suddenly goes awry? The heart rate, digestion, blood pressure — all operate on their own rhythm, sometimes missing a beat or accelerating when it should not. This is the world of those living with dysautonomia. Beyond the scientific terms and medical jargon, it’s about people striving for stability amidst a sea of unpredictability. In this article, we’ll dive deep into the 15 types of dysautonomia, not just as clinical definitions but as lived experiences, hoping to shed light on a topic that touches millions yet remains in the shadows.

What Is Dysautonomia?

Dysautonomia is an umbrella term for various disorders that impact the autonomic nervous system (ANS). This system effortlessly regulates heart rate, blood pressure, and digestion. Imagine apps in our body malfunctioning. About 70 million people globally feel this: racing hearts when standing, unpredictable digestion, temperature sensitivities, or fatigue. The causes vary. It can be a primary condition or secondary, stemming from diseases like diabetes, multiple sclerosis, or Parkinson’s.

The Autonomic Nervous System: Why It Matters

The autonomic nervous system, with its sympathetic and parasympathetic branches, is our body’s balancing act.

Sympathetic System: This “fight or flight” mechanism guards us against threats. It quickens our heart, sharpens our pupils, pauses digestion, and powers our muscles.

Parasympathetic System: As the “rest and digest” counterpart, it calms the storm after danger. It eases the heart, aids digestion, and conserves energy, letting us recover and recharge.

The autonomic nervous system auto-controls crucial tasks — digesting meals, adapting to temperatures, or prepping for challenges. But when it misfires, like in dysautonomia, the impact is profound.

Common Signs and Symptoms of Dysautonomia

Dysautonomia presents a range of often overlooked symptoms. Here’s a breakdown of the common signs those with the condition might experience:

  • Orthostatic intolerance: Dizziness or lightheadedness upon standing up.
  • Tachycardia: An unusually rapid heart rate, especially when moving from lying down to standing up.
  • Blood pressure fluctuations: It can either be too high or too low, leading to fainting spells or feelings of dizziness.
  • Digestive issues: Including bloating, constipation, diarrhea, and acid reflux.
  • Temperature dysregulation: Sensitivity to heat or cold, inability to regulate body temperature, leading to excessive sweating or chills.
  • Fatigue: Persistent tiredness or weakness regardless of the amount of rest.
  • Exercise intolerance: Difficulty or discomfort when engaging in physical activity, even mild forms.
  • Blurry vision: Particularly upon standing or changing positions.
  • Dry eyes and mouth: Persistent feelings of dryness, leading to discomfort or difficulty swallowing.
  • Breathing difficulties: Shortness of breath, even without much physical exertion.
  • Sleep disturbances: Trouble falling asleep, staying asleep, or experiencing nonrestorative sleep.
  • Frequent headaches or migraine: Often exacerbated by changes in position.
  • Cognitive challenges: include brain fog, difficulty concentrating, or memory issues.
  • Pupil dilation: Excessive or inappropriate dilation of the pupils in various light conditions.
  • Chest pain: Discomfort in the chest area, not necessarily related to cardiac issues.
  • Nausea or vomiting: Especially upon changing body position or after eating.
  • Muscle pain or weakness: Discomfort or difficulty in muscle movement or function.
  • Mood fluctuations: Including depression, anxiety, or mood swings.
  • Cold or discolored hands and feet: Due to poor circulation or blood flow issues.
  • Palpitations: Sensations of skipped heartbeats or a fluttering heart.

Understanding these symptoms is crucial because dysautonomia can often be misdiagnosed or overlooked, given the broad range of presentations. Recognizing them can lead to better management, support, and quality of life for those affected.

Primary Autonomic Disorders

1. Postural Orthostatic Tachycardia Syndrome (POTS)

A subtype of dysautonomia, POTS causes a quick heart rate increase when standing up from lying down, leading to dizziness, fainting, and fatigue. It affects the system controlling automatic body functions. Its exact cause is unclear but might be linked to infections, trauma, or surgery.

Management includes increased fluid and salt intake, compression garments, and medications to regulate heart rate and blood pressure.

2. Pure Autonomic Failure (PAF)

Pure autonomic failure impacts the autonomic nervous system, causing a loss of its functions. Those with PAF often feel dizzy or faint due to a blood pressure drop when standing. They might also have urinary issues, sweating problems, and sexual dysfunction. Its cause is unclear, but it mainly affects older adults.

While there’s no cure, treatment focuses on managing symptoms, such as medications to increase blood pressure or lifestyle changes to minimize dizziness.

3. Hereditary Sensory and Autonomic Neuropathies (HSAN)

HSAN is a group of uncommon genetic disorders affecting sensory and nerve functions. People with HSAN may not feel pain or temperature changes, causing missed injuries. They can also have abnormal sweating, swallowing problems, and bladder troubles. Symptoms differ across HSAN types, usually appearing in early life due to genetic mutations.

Management focuses on symptom alleviation, injury prevention, and addressing specific complications arising from sensory and autonomic deficits.

4. Familial Dysautonomia (Riley-Day Syndrome)

This is a genetic disorder impacting the autonomic and sensory nerves. It starts at birth with symptoms like feeding issues and frequent lung infections. As one ages, they might not feel temperature changes, have dry eyes, face blood pressure issues, and have swallowing troubles. Stress can also cause vomiting or high blood pressure episodes.

Caused by a mutation in the IKBKAP gene, management centers around alleviating symptoms and preventing complications with a multidisciplinary approach involving various therapies and medications.

5. Multiple System Atrophy (MSA)

This is a neurodegenerative disorder impacting the autonomic nervous system and movement. It has symptoms similar to Parkinson’s, such as tremors and muscle stiffness. MSA also causes blood pressure drops when standing, bladder problems, and sleep-related breathing difficulties. The cause is unclear; while there’s no cure, its progression can differ among individuals.

Treatment for MSA is symptomatic, aiming to improve quality of life by managing specific symptoms through medications, physical therapy, and supportive care.

6. Baroreflex Failure

Baroreflex failure is a rare condition where the body can’t maintain stable blood pressure. It results from damage to the baroreceptors or their neural pathways, leading to blood pressure spikes and drops. Symptoms include severe headaches, excessive sweating, and flushed skin.

Treatment focuses on managing blood pressure fluctuations and alleviating symptoms.

Secondary Autonomic Disorders

7. Neurocardiogenic Syncope (NCS) or Vasovagal Syncope

Neurocardiogenic syncope (NCS) or vasovagal syncope is the most common cause of fainting. It results from a drop in blood pressure or slowed heart rate, typically triggered by stress, pain, or prolonged standing. This leads to reduced blood flow to the brain, causing brief unconsciousness.

Recovery is usually rapid, and management involves identifying and avoiding triggers.

8. Hypovolemic Orthostatic Intolerance

Hypovolemic orthostatic intolerance is characterized by a decrease in blood volume (hypovolemia), leading to symptoms upon standing or prolonged upright posture. These symptoms include dizziness, lightheadedness, and fainting due to insufficient blood flow to the brain. Causes can be dehydration, blood loss, or inadequate salt intake.

Treatment often involves increasing fluid and salt consumption.

9. Autoimmune Autonomic Ganglionopathy (AAG)

Autoimmune autonomic ganglionopathy (AAG) is a rare disorder where the immune system mistakenly attacks autonomic ganglia, disrupting involuntary bodily functions. Symptoms can include orthostatic hypotension, digestive issues, and reduced sweating.

Often triggered by an underlying tumor or another autoimmune disorder, AAG’s treatment focuses on immune suppression and symptom relief.

10. Post-Viral Dysautonomia

This occurs after a viral infection when the immune response inadvertently affects the autonomic nervous system. Symptoms mirroring other forms of dysautonomia include fatigue, heart rate irregularities, and dizziness. The exact cause linking the viral infection to dysautonomia remains unclear.

Management focuses on treating individual symptoms and supportive care.

11. Diabetic Autonomic Neuropathy

Diabetic autonomic neuropathy (DAN) is a complication of diabetes resulting from damage to the autonomic nerves. This can affect various bodily functions, including digestion, bladder control, heart rate, and blood pressure regulation. Common symptoms include gastroparesis (delayed stomach emptying), urinary issues, and orthostatic hypotension.

Proper glucose management is crucial to prevent or slow the progression of DAN, with treatments addressing specific symptoms.

12. Autonomic Dysreflexia

Autonomic dysreflexia is a potentially life-threatening condition that affects those with spinal cord injuries, typically above the T6 level. Triggered by an irritating stimulus below the damage, like a full bladder or bowel, it manifests as a sudden, severe spike in blood pressure accompanied by headaches, flushed skin, and sweating.

Immediate medical attention is crucial, and treatment involves identifying and removing the triggering stimulus.

13. Secondary Autonomic Failure

Secondary autonomic failure refers to disorders in which autonomic dysfunction is not the primary manifestation but arises due to another underlying condition. Causes can include diabetes, Parkinson’s disease, and certain medications. Symptoms mirror primary autonomic disorders, such as dizziness, irregular heart rate, and digestive issues.

Treatment focuses on managing the underlying condition and alleviating autonomic symptoms.

Other Forms of Dysautonomia

Dysautonomia can also be associated with other conditions.

14. Paraneoplastic Syndrome-Associated Dysautonomia

This refers to autonomic disturbances arising not directly from the cancer but from the body’s immune response to specific tumors. The immune system mistakenly targets normal tissues, affecting the autonomic nervous system. Symptoms can include gastrointestinal, cardiovascular, or urinary dysfunctions.

Recognizing and treating the underlying tumor is paramount, and symptom relief often follows tumor management or removal. Immune therapies may also be used to address the paraneoplastic syndrome directly.

15. Guillain-Barré Syndrome (GBS)

Guillain-Barré syndrome-associated dysautonomia occurs when the body’s immune response, typically following an infection, mistakenly attacks peripheral nerves, including those of the autonomic nervous system. This can lead to autonomic dysfunctions such as abnormal heart rate, blood pressure fluctuations, and bowel or bladder disturbances. While GBS primarily presents with muscle weakness and paralysis, the autonomic symptoms can complicate management.

Treatment typically involves immunotherapies like intravenous immunoglobulin or plasma exchange, and as GBS symptoms improve, the dysautonomic features often resolve or lessen.

Diagnosis For Dysautonomia

Diagnosing dysautonomia can be complex due to its varied manifestations and overlap with symptoms of other disorders. However, a systematic approach is taken to confirm the diagnosis:

  • Medical history: Gather patient symptoms, onset, frequency, triggers, and family history.
  • Physical examination: Check for symptoms like blood pressure changes upon standing.
  • Tilt table test: Assesses blood pressure and heart rate reactions to posture changes.
  • QSART: Measures nerve-induced sweating in body regions.
  • Autonomic breathing test: Monitors blood pressure and heart rate during forced breathing.
  • 24-Hour urine test: Evaluates specific urine chemicals hinting at autonomic dysfunction.
  • Skin biopsy: Checks for small fiber neuropathies related to dysautonomia.
  • Blood tests: Rule out other conditions or find markers for certain dysautonomias.
  • Specialized tests: Includes cardiac monitoring, gastric studies, or sweat tests as needed.

It’s essential to approach the diagnosis holistically, considering all possible contributing factors.

Different Treatments for Dysautonomia

Treatment for dysautonomia largely depends on the specific type and severity of the condition. The primary goal is to relieve symptoms, improve quality of life, and treat any underlying cause if identified. Here are the general treatment approaches for dysautonomia:


  • Blood pressure drugs: Fludrocortisone, midodrine, and others regulate blood pressure.
  • Anticholinergic drugs: Address overactive bladder or excessive sweating.
  • SSRIs: Alleviate associated depression or anxiety.
  • Ivabradine: Slows heart rate, especially for POTS.
  • Pyridostigmine: Modifies standing blood pressure without affecting it when lying down.

Diet and Lifestyle:

  • Salt and fluids: Combat low blood pressure and dizziness.
  • Compression stockings: Prevent blood pooling in the legs.
  • Exercise: Maintain muscle tone and blood flow; specific activities can be beneficial.
  • Bed elevation: Reduces morning dizziness.


  • Biofeedback: Control physiological functions.
  • Physical therapy: Improve balance and muscle strength.
  • Cognitive behavioral therapy (CBT): Manage anxiety, depression, and coping.

Invasive Treatments:

  • Pacemaker: Used in cases with heart rate issues.
  • Plasma exchange/IVIG: For autoimmune dysautonomia variants.

Alternative Treatments:

  • Acupuncture: Offers symptom relief for some.
  • Massage: Improves circulation and eases muscle issues.

Regular Check-Ups:

Chronic dysautonomia requires ongoing monitoring to adapt treatments and introduce new strategies.

While there is no cure for dysautonomia, many people can lead a full life with appropriate management. Patients must work closely with their health care provider to develop an individualized treatment plan tailored to their needs and symptomatology.

Impact of Dysautonomia

Living with dysautonomia presents multifaceted challenges that touch every aspect of life.

Intimacy can be strained in personal relationships as partners wrestle with the disorder’s unpredictability. Parents might grapple with guilt, while children with the condition can feel isolated or different.

Career-wise, frequent medical needs and fatigue can hinder job performance and limit professional growth. The invisible nature of dysautonomia often leads to misunderstandings at the workplace. Moreover, the condition can shape one’s self-perception, leading to identity crises and diminished self-worth.

Students may face academic hurdles, and once-loved hobbies might need modification. Given the misconceptions surrounding this condition, individuals often find themselves advocating and educating, which, while essential, can be mentally exhausting.

As such, a supportive and understanding circle becomes invaluable for those navigating this journey.

Tips for Navigating Life With Dysautonomia

Living with dysautonomia can be challenging, but you can lead a fulfilling life with the right strategies and support. Here are some practical tips to help navigate daily life with this condition:

  1. Learning about your situation is empowering and helps others understand your journey.
  2. Keep medical records and daily plans organized; a little structure can make unpredictable days feel more manageable.
  3. Your mental well-being matters; talk to someone or find a group where you’re heard and understood.
  4. Plan outings with care. Knowing your limits is a sign of strength, not weakness.
  5. Make little changes at home or work that make the big picture more comfortable.
  6. Listen to your body’s needs; hydrate and nourish it with love and care.
  7. Gentle movements can be healing; find an activity that feels right.
  8. Embrace tools and tech that assist, whether a walking stick or a health app.
  9. Stay curious about new research.
  10. Celebrate the small victories and cherish moments of calm.

Navigating the maze of dysautonomia can feel overwhelming, but you’re not alone. Every type, symptom, and challenge carries a story of resilience. Remember, seeking understanding is a brave step forward. With shared knowledge and mutual support, we create a comforting blanket of hope and strength for everyone affected.

Getty image by Madrolly

Originally published: October 17, 2023
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